It can be done that other non determined ABC proteins confer Mitox resistance in these two cell lines. It requirements the further investigations.
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Additionally, the cytotoxicity Increased by Zosuquidar was identified for being far more strong than that by cyclosporine A in cells with hugely Energetic P-gp. These in vitro experiments suggest that zosuquidar could possibly be a successful adjunct to cytotoxic chemotherapy for AML patients whose blasts Specific P-gp, especially for more mature people than age sixty decades.
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These in vitro reports suggest that zosuquidar could possibly be an efficient adjunct to cytotoxic chemotherapy for AML clients whose blasts Categorical P-gp, specifically for older individuals.
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The result of Zosuquidar 3HCl on paclitaxel AUC displays the reduce in paclitaxel CL for a consequence of P-gp inhibition. Hence it absolutely was applicable to design this PK interaction on paclitaxel CL as opposed to on exposure.